EdenteV2, Main, Exploration, bibRecord, 002536

Effect of chronic kidney disease on the healing of titanium implants

Identifieur interne : 002536 ( Main/Exploration ); précédent : 002535; suivant : 002537

Effect of chronic kidney disease on the healing of titanium implants

Auteurs : Huawei Zou [République populaire de Chine] ; Xuefeng Zhao [République populaire de Chine] ; Ningyuan Sun [République populaire de Chine] ; Shiwen Zhang [République populaire de Chine] ; Tadatoshi Sato [États-Unis] ; Haiyang Yu [République populaire de Chine] ; Qianming Chen [République populaire de Chine] ; Hans-Peter Weber [États-Unis] ; Michel Dard [États-Unis] ; Quan Yuan [République populaire de Chine, États-Unis] ; Beate Lanske [États-Unis]

Source :

Bone [ 8756-3282 ] ; 2013.

RBID : PMC:3812922

Abstract

Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For in vitro tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812922

DOI: 10.1016/j.bone.2013.07.014
PubMed: 23876979
PubMed Central: 3812922

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For <italic>in vitro</italic>
 tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.</p>
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Effect of chronic kidney disease on the healing of titanium implants

Effect of chronic kidney disease on the healing of titanium implants

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